The episcopate moves from Osor to Cres in the 15th century.

As the economic and political power of landowner families in Cres rose, many palaces were built in Cres. Palaces of Cres patricians, who were locally called vlastela, were the upper class of the society that separated from commoners in the 15th century during the Venetian Republic. Patricians assuming political power possessed large properties outside the city and owned palaces in the city. Ground floors of their palaces were designed as spacious areas intended for crafts and trade and also served as wine cellars and huge store rooms for crops. Some of these palaces are: the Petris Palace, Rodinis Palace, Moise Palace and Colombis Palace all of which are built in the Venetian Gothic and early Renaissance style.